Ameliorative effect of vitamin e on oxidative stress induced by bisphenol a in female albino rats

Objective: Oxidative stress is induced by bisphenol A [BPA] and affects many organs. Vitamin E is an effective antioxidant which prevents the activity of free radicals. This study was aimed to clarify the effect of vitamin E on the oxidative stress induced by chronic administration of BPA

Materials and methods: 30 female albino rats were divided into 3 groups [10/each]; group1: control rats, group 2: rats treated with bisphenol A [20 mg/ kg.B.wt] for three months, and group 3: rats treated with bisphenol A [20 mg/kg.B.wt] for three months, then treated with BPA and vitamin E [0.57/100 g B.wt] for other 15 days

Results: BPA induced hormonal disrupt in liver and kidney dysfunctions and hyperlipidemia. Vitamin E ameliorated all these parameters

Conclusion: since we exposed to many harmful disruptions and oxidative stress compounds, we must take vitamin E as a protective agent

potential protective effect of stem cell enhancer on chronic bisphenol-a treated female albino rats

Background: The xenoestrogen, bisphenol-A [BPA], is a worldwide food contaminant with endocrine disruptor activity that is incorporated in many plastic industries. The exposure of humans to such substances starts early during the fetal life, postnatal life and extends throughout the life of the individual. Many agencies raised warnings against the excessive use of these substances

Aim of the work: The present study was designed to determine if the usage of stem cell enhancer [SE] moderates the physiological changes occasioned by exposure to BPA in the female albino rats

Materials and Methods: This study was performed on thirty female albino rats with an average 100-120 g body weight. The animals were divided into three groups; Group I [Control untreated-group], Group II [bisphenol­A treated group] and Group III [treated group orally supplied with bisphenol ­A then treated with stem cell Enhancer [SE]]. Serum was separated and used for estimation of hormonal levels [estradiol, progesterone, prolactin [PRL], follicle-stimulating hormone [FSH] and luteinizing hormone [LH]], some biochemical parameters [liver enzymes, kidney function, glucose and lipid profile] and CA-125 and CA 15-3 tumor markers

Results: The biochemical results showed marked significant increase [P<0.01] in the enzyme activities [aspartate aminotransferase [ASAT], alanine aminotransferase [ALAT] and alkaline phosphatase [ALP]], urea and creatinine in bisphenol­A treated group when compared to the control group. These parameters were significantly reduced in the group treated with stem cell enhancer as compared to bisphenol ­A treated group. Decline in the concentration of lipid profile with increase in high density lipoprotein cholesterol [HDL- C] levels in the stem cell treated group as compared to bisphenol-A group were observed. There was a significant elevation in prolactin, FSH and tumor marker levels concomitant with a significant reduction in LH levels in bisphenol-A treated group compared to the control group. These results were changed to values very close to control by using the stem cell enhancer

Conclusion: It could be concluded that bisphenol-A has dangerous effects on liver and kidney functions as well as on lipid profile, female hormones and tumor markers level. So, we recommended minimizing the utililizing of this compound and the use of some protective materials as stem cell enhancer to protect people from its hazardous effects

Potential effect of Aloe barbadensis and Salvadora persica [Miswak] Mixture Sap as a contraceptive therapy in female mice

Background: Evaluation of herbs has been in progress worldwide for several decades to identify effective and safe substances for fertility regulation. This approach proved to be a good alternative to synthetic drugs as the chemicals of plant origin have limited side effects. Various medicinal plant extracts were investigated for their antifertility activity in female animal models

Aim of the work: This study was designed to investigate the toxic effects of Aloe barbadensis and Salvadora persica [Miswak] Mixture sap and to assess them as a contraceptive therapy

Material and Methods: Twenty female adult albino rats [Sprague dawley strain] were used in this study. Rats were divided into two groups [10 rats in each group]; Group I [control untreated group] and Group II [mix treated group]. Mixture of Aloe barbadensis and Miswak sap was orally administered [7 mg of Miswak + 7 mg of Aloe per 100 gram body weight] for 30 +/- 2 days, where females were in the diestrus phase]. All animals were decapitated after 30 days and blood samples were analyzed for estrogen, progesterone, tumor markers CA-15.3 and CA-125, kidney and liver functions, proteins profile and lipids profile

Results: The mean serum level of estrogen was significantly increased [p<0.01], while that of progesterone was significantly decreased [p

Conclusion: It could be concluded that Aloe barbadensis and Miswak extract can be used as a safe contraceptive therapy that can increase the estrogen level due to its phytoestrogen components such as beta sitosterol, without deleterious effects on the vital organs [liver and kidneys]

Studies on the use of Aloe vera extract as a contraceptive in female rats

Background: The study on the natural herbal contraception has become one of the main interests of modern contraceptive studies. Herbs have been used by women since the beginning of time in an attempt to control their fertility. The development of new fertility regulating drugs derived from medicinal plants is an attractive proposition, Aloe Vera is a durable plant belonging to Sousanian family

Aim of the work: This work was assessed to evaluate the probable contraceptive effect of the aqueous extract of Aloe vera plant and its effect on the some vital organs in the female albino rats

Materials and Methods: This study was performed on twenty female albino rats with an average 120-140g body weight. The animals were divided into two groups [5 /cage]; Group I [Control untreated group] and Group II [Aloe vera group that supplied orally with 7 mg/kg body wt/day of the plant extract for 30 +/- 2 days].Results A prolonged proestrus and estrus phases of the estrous cycle were observed in the Aloe vera group .The mean serum level of estrogen [estradiol] was significantly increased in the Aloe vera group as compared to the control group [P<0.01] while non significant difference was found for serum level of progesterone and the tumor markers, CA15-3 and CA-125.The results also showed a marked decline [p<0.01] in levels of the serum calcium, creatinine, urea, total proteins, albumin, globulin and ratio of TC/HDL accompanied with a marked elevation [p<0.01] in the serum phosphorus, total lipid, TC, TG, HDL and LDL levels in the Aloe vera group in comparison with those of control group. However, levels of uric acid, AST, ALT, GGT, VLDL and ratios of LDL/HDL [risk factors] and A/G were approximately as that of the control group

Conclusion: It could be concluded that Aloe vera can be used as a contraceptive drug that can increase the estrogen level due to its phytoestrogen components such as beta sitosterol and without deleterious effects on the other vital organ [liver and kidney], however it's use is to be restricted with women suffering from low ca++level as well as osteoporosis

effects of Jasonia montana [neheda] on some biochemical and histological parameters of diabetic albino rats

Diabetes mellitus is one of the common and widely distributed metabolic diseases all over the world. This disease is characterized by hyperglycemia that results from defects in insulin secretion, insulin action or both. In Asia, different medicinal plant species are used as a traditional treatment for diabetes mellitus e.g. Jasonia montana [Neheda] was one of these plants that was used in a mixture to treat diabetic patients long times ago. This work was aimed to investigate the antidiabetic, hypolipidemic and antioxidant effects of the aqueous extract of Jasonia montana [Neheda] on the alloxan-induced diabetic male albino rats. This study was performed on thirty male albino rats with an average 100-110 g body weight. The animals were divided into three groups [10 /cage]; Group I [Control untreated group], Group II [Alloxan-induced diabetic group] and Group III [diabetic group treated orally with "28.5 mg/ kg body wt. twice/ day" of the plant extract]. The biochemical results showed marked decline [p<0.01] in levels of the serum insulin, body weight, total proteins, albumin, globulin and HDL accompanied with marked elevation [p<0.001] in the levels of fasting blood glucose, levels of HOMA_IR, AST, ALT, GGT, urea, creatinine, uric acid, serum TC, TG, LDL, VLDL and ratios of TC/HDL and LDL/HDL [risk factors] in diabetic rats in comparison with the control group. Daily management of diabetic rates with aqueous extract of Neheda showed significant improvement in most of these parameters. Histologically, considerable improvement in the morphological changes that was observed in diabetic groups had been detected after treatment with Neheda in liver, kidney and pancreatic tissues in comparison to the control group. It could be concluded that Jasonia montana [Neheda] can be used as an antidiabetic drug that can lower blood glucose concentration and guard against the negative effects of diabetes

Habitat characteristics for different freshwater snail species as determined biologically through macroin- vertebrate information

Macro-invertebrates including freshwater snails collected from 643 sites over 8 successive seasons among the River Nile, branches, main canals and certain drains in eight Egyptian Governorates. Thirteen snail species and one bivalve species were identified. The most distributed were Lanistus carinatus and Physa acuta while the most abundant were Cleopatra bulimoides and Physa acuta during the whole study. The sites that harbored each snail species in all the examined watercourses were grouped seasonally and their biological assessment was determined by their minimum and maximum total point similarity percentage to that of the corresponded reference site and mean of the total points. Habitats for most snail species attained minimum total point's similarity percentage less than 21% [very poor habitat] during autumn and winter then spring while during summer very poor habitat was harbored by only few snail species. P. acuta was the only survived snails in habitat which attained 0 as a minimum total point's similarity percentage during two seasons and L. carinatus and Succinea cleopatra during one season. With respect to medically important snails very poor sites constituted 23% of Biomphalaria alexandrina sites, 14% of Lymnaea natalensis and 9.4% of Bulinus truncatus sites. The studied macroinvertebrate matrices, total number of organisms, taxa richness, the Ephemeroptera, Plecoptera, and Trichoptera [EPT] index, ratio of EPT index to chironomidae, ratio of scraper to filtering collector, contribution of dominant macroinvertebrate major group, comparison revealed descending tolerances from B. alexanrina followed by L. natalensis then B. truncates, but Hilsenhoff Biotic Index [HBI] showed the same tolerance to organic pollution